Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase.
نویسندگان
چکیده
Tetrahydrobiopterine (6BH(4)) can diminish the oxidative stress undergone by keratinocytes and melanocytes by reducing the o-quinones generated by the oxidation of the corresponding o-diphenols. We found that 6BH(4) and their analogs reduced all the o-quinones studied. The formal potentials of different quinone/diphenol pairs indicate that the o-quinones with withdrawing groups are more potent oxidants than those with donating groups.
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 74 5 شماره
صفحات -
تاریخ انتشار 2010